rLG3: RESTORING THE BRAIN’S ABILITY TO REPAIR ITSELF

rLG3 is a first-in-class recombinant biologic derived from a natural protein (Perlecan) that activates the brain’s innate repair systems.

rLG3 is from Stream’s portfolio of vascular matrikine therapies. Stream has identified the amino acid sequence of Perlecan that reverses the underlying pathology that drives neuronal loss and cognitive impairment.

Why rLG3

• First-in-class recombinant biologic designed to activate the brain’s natural repair systems
• Engages multiple pathways involved in vascular integrity, inflammation, and neuronal recovery
• Targets neurovascular dysfunction as an upstream driver of neurodegeneration
• Demonstrated activity across multiple preclinical models
• Demonstrated safety in toxicological studies 

Why It Matters

• A transformative approach to treating neurodegeneration
• Supported by strong mechanistic and preclinical studies
• Targets the root cause of many neurodegenerative diseases
• Protects, repairs, and restores the brain
• Broad therapeutic potential: Alzheimer’s disease, stroke, traumatic brain injury, and others