Revolutionizing Cerebrovascular Repair

Revolutionizing Cerebrovascular Repair Revolutionizing Cerebrovascular Repair Revolutionizing Cerebrovascular Repair

Developing Novel Solutions for Neurotrauma and Neurodegeneration

STROKE

TRAUMATIC BRAIN INJURY

ALZHEIMER'S DISEASE

A New Class of Therapeutics

Stroke - PBS at Reperfusion

3D Visualization of neurovascular drop-out after experimental stroke in mice treated with saline (72 hours post-injury)

Stroke - LG3 at Reperfusion

3D Visualization of neurovascular protection of the same mice after treatment with LG3 (72 hours post-injury)

Publications

Internal Publications

Recombinant Human Perlecan DV and Its LG3 Subdomain Are Neuroprotective and Acutely Functionally Restorative in Severe Experimental Ischemic Stroke

External Publications

Perlecan Domain-V Enhances Neurogenic Brain Repair After Stroke in Mice

Caspase-3 Activation Triggers Extracellular Cathepsin L Release and Endorepellin Proteolysis

Epidermal Growth Factor and Perlecan Fragments Produced by Apoptotic Endothelial Cells Co-Ordinately Activate ERK1/2-Dependent Antiapoptotic Pathways in Mesenchymal Stem Cells

Perlecan Domain V Inhibits Amyloid-β Induced Brain Endothelial Cell Toxicity and Restores Angiogenic Function

Perlecan domain V inhibits alpha-2 integrin-mediated amyloid-beta neurotoxicity

Press Releases

Stream Biomedical, Inc., a privately held clinical-stage biopharmaceutical company, is dedicated to the development of first-in-class targeted therapeutics for the treatment of acute neurotrauma and chronic neurodegenerative diseases of high unmet need.

March 04, 2025

Stream Biomedical, Inc. Announces Acceptance of Abstract for Presentation at Annual Meeting of the American Society of Neurotherapeutics (ASENT) Conference 2025

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Stream Biomedical, Inc.

2450 Holcombe Boulevard, Suite J Houston, TX 77021

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