rLG3 Reverses Alzheimer's Pathology

Reduces Alzheimer's (AD) Plaque Burden in key brain structures
- Brain-wide effect in young females
  - Greatest effect in hippocampus
- Amygdala specific in aged males
Improves blood-brain barrier integrity (tight junction protein expression)
Improves Alzheimer's-related behavioral and functional deficits
- Rescues exploratory behavior
- Improves spontaneous alternation
- Trend toward improved object memory (small n= for memory assessments)
Reduces amyloid burden in amygdala

5xFAD Data Highlights