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5xFAD Model Data Highlights

Female Data (Amyloid plaque & tight junctions information)

lg3 effective in Alzheimer's model

Consistent with neurovascular hypothesis of cause of AD

  • Reduces Alzheimer's (AD) Plaque Burden in key brain structures
    • Brain-wide effect in young females
      • Greatest effect in hippocampus
    • Amygdala specific in aged males
  • Improves blood-brain barrier integrity (tight junction protein expression)
  • Improves Alzheimer's-related behavioral and functional deficits
    • Rescues exploratory behavior
    • Improves spontaneous alternation
    • Trend toward improved object memory (small n= for memory assessments)
  • Reduces amyloid burden in amygdala

Male Data (Functional assessments & AB42 in Basolateral Amygdala)

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